Dual Acylation of PDE2A Splice Variant 3

The neuronal PDE2A3 splice variant is targeted to membranes via dual acylation

Background The cyclic nucleotide second messengers cAMP and cGMP play key roles in mammalian signal transduction. Their intracellular levels are tightly controlled by the rate of synthesis and degradation. Hydrolysis of the cyclic nucleotides is dependent on the activity of phosphodiesterases (PDE) of which to date 11 families have been identified. The cGMP-stimulated cGMP/cAMP phosphodiesteras...

Dual-specificity splice sites function alternatively as 5' and 3' splice sites.

As a result of large-scale sequencing projects and recent splicing-microarray studies, estimates of mammalian genes expressing multiple transcripts continue to increase. This expansion of transcript information makes it possible to better characterize alternative splicing events and gain insights into splicing mechanisms and regulation. Here, we describe a class of splice sites that we call dua...

Mouse Specific Cleavage-Resistant RAGE Splice Variant

Receptor for Advanced Glycation Endproducts (RAGE), a transmembrane, multi-ligand, pattern recognition receptor, has been implicated in a range of inflammatory disease including diabetes, cancers, and cardiovascular disease (CVD) [1]. In addition to the full length receptor, soluble form of RAGE (sRAGE) has been shown to prevent the development of numerous pathologic states, and therefore highl...

Comparison of Expression of Growth Hormone-Releasing Hormone and Its Receptor Splice Variant 1 in Different Stages of Endometriosis

Splice Variant Search with Gene Expression Data

Alternative splicing is the phenomena that the pre-mRNA transcript from DNA is processed into different mRNAs by spliced different types of introns. The organism can acquire proteins as many times as genes. Therefore to find such splicing variants is risen in the post genome era. We investigate a new method to detect splicing variants with the gene expression data by the oligonucleotide array t...